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1 ). To prioritize related SNPs for comply with up analyses, we used a Bayesian approach to derive the smallest set of variants that included the causal variant with ninety five% likelihood (95% credible set) ( 7 ). 5 SNPs had been included in this ninety five% credible set ( SI Appendix, Desk S1 ). We then conducted a replication association evaluation of these 5 SNPs in an independent cohort of 222,358 males (2,957 circumstances and 219,401 controls) from the UK Biobank ( SI Appendix, Desk S2 ). All five credible set SNPs were considerably viagra for women associated with erectile dysfunction in the replication evaluation (P zero.01 required for multiple testing; all SNPs had been related P 0−thirteen) in the same route as the GERA cohort outcomes ( SI Apendix, Table S3 ). As evolutionary conservation is a strong marker of purposeful genomic sequences, we centered our follow-up analyses on one of the 5 SNPs, rs17185536, which was the only SNP positioned in an evolutionarily conserved area ( 8 ).
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